Abstract
Introduction: Tumor-associated macrophages (TAMs), key components of tumoral microenvironment, impact prognosis in different cancer subtypes. Previously reported data from Humanitas University group showed that TAMs morphology correlates with prognosis in colorectal liver metastases (CLMs), with smaller TAMs (S-TAMs) conferring a more favourable prognosis than larger ones (L-TAMs). This study aimed to externally validate TAMs morphology as a prognostic factor in resected CLMs.
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