Abstract
Wistar King A rats were immunized with homologous thyroglobulin in complete Freund's adiuvant with pertussis vaccine. The relationship between different parameters of the immune response to thyroglobulin and the inflammatory reaction of the thyroid gland was observed. The severity of thyroiditis reached its peak 3 weeks after immunization in all animals. Regression of both the inflammatory cell reaction and the degree of follicular damage began from the 4th week. Hemagglutinating antibody titer to thyroglobulin reached its peak 3 to 4 weeks after immunization and persisted until the 10th week. Delayed type skin hypersensitivity to thyroglobulin was less well correlated with the degree of thyroiditis. However, the migration inhibition of peritoneal exudate cells by thyroglobulin in vitro correlated with the development of thyroiditis, and approximately 50% inhibition was observed 2 to 5 weeks after immunization. Chemotactic activity of the macrophages to thyroglobulin by the modified Boyden chamber technique was markedly increased in the 3rd week after immunization. No chemotactic response to kidney extract was noticed during the time of observation. These results give a clue to the mechanism of accumulation of macrophages in the thyroid in experimental allergic thyroiditis.
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