Abstract
miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart.The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosoland translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155-containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice.
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