Abstract
We investigated the serum level of macrophage colony stimulating factor (M-CSF) in patients with hepatitis using a newly developed radioimmunoassay (RIA). The mean level of M-CSF in patients with chronic active hepatitis was significantly higher than that of the healthy controls (P < 0.01). The mean level of M-CSF in patients with acute hepatitis in the acute phase was prominently higher than that of the patients with chronic active hepatitis (P < 0.001). However, in the convalescence phase of acute hepatitis, the mean level of M-CSF decreased to the lower level comparable to the mean level of the patients with chronic active hepatitis. These data suggest that the serum level of M-CSF is one of the factors which represents the inflammatory activity of liver diseases.
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