Macronutrient Intake and Risk of Dementia in Community-Dwelling Older Adults: A Nine-Year Follow-Up Cohort Study.

Abstract

Little is known about the association between macronutrient intake and incident dementia. To identify an optimal range of macronutrient intake associated with reduced risk of dementia. Our analysis included 93,389 adults aged 60-75 years from the UK Biobank. Diet was assessed using a web-based 24-h recall questionnaire between 2009-2012. Dementia was ascertained using hospital inpatient, death records, and self-reported data up to January 2021. We calculated a macronutrient score based on associations between an individual's macronutrient intake and incident dementia. During a median follow-up of 8.7 years, 1,171 incident dementia cases were documented. We found U-shape relationships for carbohydrate, fat, and protein intake with incident dementia. Compared to individuals with optimal carbohydrate intake, those with high intake (HR (95%CI): 1.48(1.15-1.91)) but not low intake (1.19(0.89-1.57)) had a higher risk of dementia. In the multivariable analysis, a low-fat intake (HR (95%CI): 1.42(1.11-1.82)) was associated with a higher risk of all-cause dementia. After adjustment for covariates, a high (HR (95%CI): 1.41(1.09-1.83)) but not low protein intake (1.22(0.94-1.57)) was associated with an increased risk of dementia. Individuals in quintiles 3-5 of optimal macronutrient score had a lower risk of dementia compared with those in quintile 1 (HR (95%CI): 0.76(0.64-0.91) for quintile 3, 0.71(0.60-0.85) for quintile 4, 0.74(0.61-0.91) for quintile 5). The association between macronutrient score and incident dementia was significant across subgroups of age, gender, education, and smoking. Moderate intakes of carbohydrate, fat, and protein were associated with the lowest risk of incident dementia.