Macromolecular Recognition: Interaction of Cyclodextrins with an Alternating Copolymer of Sodium Maleate and Dodecyl Vinyl Ether

Abstract

AbstractInteraction of cyclodextrins (CDs) with an alternating copolymer of sodium maleate and dodecyl vinyl ether (pC12MA), which forms micelle‐like aggregates in aqueous media, is investigated by several NMR techniques to explore the competition of the complexation of CDs with the dodecyl (C12) groups and the self‐association of the C12 groups. 1H NMR and two‐dimensional nuclear Overhauser effect spectroscopy data demonstrate that α‐CD interacts significantly with the C12 groups in pC12MA but β‐ or γ‐CD does not, which indicates that the competition with self‐association of the C12 groups enhances the selectivity towards α‐CD. Furthermore, the binding isotherm prepared using 1H NMR data exhibits a sigmoidal curve, which is indicative of cooperative complexation of α‐CD with pC12MA.magnified image