Abstract
Staphylococcus aureus is one of the most frequently isolated pathogens in community and hospital-acquired infections. Macrolidelincosamide-streptogramin B (MLSB) group antibiotics have frequently been preferred. In this study, it was aimed to determine MLSB group antibiotics resistance phenotypes observed in S. aureus strains. A total of 182 S. aureus strains were included in the study. Methicillin resistance was assessed using the cefoxitin (30μg) disc, MLSB resistance phenotypes were assessed using D zone test with erythromycin (15μg) and clindamycin (2μg) discs according to the Clinical and Laboratory Standards Institute (CLSI) recommendations. Of the strains included in the study, 38 (20.9%) methicillin-resistant S.aureus (MRSA) and 144 (79.1%) methicillin-susceptible S.aureus (MSSA) were identified. MLSB resistance phenotype was found in 65 (35.7%) strains. MLSB resis tance was found 84% in MRSA strains and 23% in MSSA strains: There was statistically significant between MRSA and MSSA strains. Constitutional MLSB resistance was found higher in MRSA strains (71%) and however, in MSSA strains was higher inducibleMLSB resistance (16.5%). It is suggested that, using the D test method in routine antibiotic susceptibility testing and determining resistance phenotypes in microbiology laboratories is the right approach and may play an important role in the prevention of treatment failure according to the substantial proportion of inducible resistance MLSB resistance observed.
Highlights
Staphylococcus aureus is one of the most frequently isolated pathogens in community and hospital-acquired infections
Compared to methicillin-susceptible S.aureus (MSSA) strains, cMLSB resistance phenotype was found higher in methicillin-resistant S.aureus (MRSA) strains and this was statistically significant
Macrolide-lincosamide-streptogramin group antibiotics are often used in the treatment of staphylococcal infections
Summary
Staphylococcus aureus is one of the most frequently isolated pathogens in community and hospital-acquired infections. Genes causing resistance to any of MLSB group antibiotics may lead to the development of cross-resistance to others [2,3,4].The most common mechanism of resistance to MLSB group antibiotics is carried out with methylase enzyms encoded by erm genes in the target zone. This kind of resistance is inducable by phenotypic expression of methylase enzyme (iMLSB) and may occur as constitutional resistance (cMLSB) [2,5]. It isrecommended to determine their own resistance rates of institutions due to the variations of incidence of inducible MLSB resistance between different countries, different geographic regions of countries and even health care centers [7,9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
