Macrolide Resistance–associated 23S rRNA Mutation inMycoplasma genitalium, Japan

Shigeaki Yokoi,Shin Ito,Hiroaki Ishiko,Takashi Deguchi,Shin-Ichi Ito,Mitsuru Yasuda,Keita Nakane,Masahiro Nakano,Yasushi Shimada

doi:10.3201/eid1706.101055

Abstract

Macrolide Resistance–associated 23S rRNA Mutation in<i>Mycoplasma genitalium</i>, Japan

Highlights

Strains of M. genitalium in Japan, we examined M. genitalium DNA found in the urine of men with nongonococcal urethritis (NGU) for the presence of macrolide resistance–associated mutations in the 23S rRNA gene and the ribosomal protein genes L4 and L22
We found a T-to-G transition at nucleotide position 2199 in the 23S rRNA gene of M. genitalium, corresponding to position 2185 in E. coli, in 3 specimens, but this mutation has not been associated with macrolide resistance in other bacterial species [9]
Mutations in the 23S rRNA gene and amino acid changes in L4 and L22 ribosomal proteins of 25 Mycoplasma genitalium strains in the pretreatment urine specimens of men with nongonococcal urethritis, Japan

Summary

Introduction

Novel respiratory virus infections in children, Brazil. Macrolide Resistance– associated 23S rRNA Mutation in Mycoplasma genitalium, Japan Mutations in the 23S rRNA gene were associated with macrolide resistance, and mutations in ribosomal protein genes L4 and L22 were found [5].

Results

Conclusion