Abstract
Macrocryoglobulinemia as the initial and predominant manifestation of systemic illness in a patient who had sarcoidosis is described and related to specific alterations in the serum immunoglobulins during the development of the disease. Ultracentrifugation of serum revealed an increase in intermediate molecular weight macroglobulin in addition to the IgM and IgG cryoglobulin complex. Immunoserologic studies demonstrated significant increases in IgA immunoglobulin and beta 1C and beta 1A globulins occurring coincident with the development of increased serum complement activity and anergy to tuberculoprotein. These changes are formulated as indicating that an unusual response to sensitization may be pathogenetically important in sarcoidosis. Alterations in serum protein fractions in sarcoidosis may be a manifestation of this immune response.
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