Abstract
Marine bio-resources are being widely studied as an invaluable source of compounds with therapeutic applicability. In particular, macroalgae contain an extended variety of bioactive compounds with different structures and promising biological applications. In this work, Ulva lactuca L. (hereafter UL) was utilyzed for the synthesis of gold and silver nanoparticles. Full characterization by UV–Vis spectroscopy, TEM, HRTEM and STEM miscroscopies, Z Potential and FTIR spectroscopy was performed. The first time in the scientific literature, the composition of carbohydrates of UL extract and their changes observed after nanoparticles synthesis were explored in order to investigate their possible role in the biosynthetic process. The reducing power, total phenolic content and DPPH scavenging activity of UL extract, Au@UL and Ag@UL nanoparticles were determined. The effects of UL extract, Au@UL and Ag@UL were tested in vitro on the colon cancer cell lines HT-29 and Caco-2, on normal primary neonatal dermal fibroblast cell line PCS-201-010, as well as on normal colon cell line CCD-112CoN. Lastly, the apoptotic activity and cellular uptake evaluation was determined for Au@UL and Ag@UL.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
