Macro‐ and nano‐oligomers ternary metal complexes preparation, structural elucidation: Antimicrobial, anticancer activities, and mechanistic study of Cu nanocomplexes on liver carcinoma

Abstract

A new binuclear transition metal complexes of Co (II) and Cu (II) have been synthesized in both bulk and nanosized formations. The complexes were synthesized by the reaction between equimolar quantities of the metal sulfate with nitrilotriacetic acid and creatine. The nanosized forms are controlled by using (CTAB). Characterization of the nanocomplexes has been done using a transmission electron microscope (TEM) and X‐ray diffraction. This technique is considered a novel approach to the synthesis of the nanoternary complexes. The Co (II) and Cu (II) complexes displayed distorted dimeric octahedral and tetrahedral structures, respectively. The prepared metal complexes were investigated by electronic spectral analysis, magnetic susceptibility measurement, infrared spectra, thermal gravimetric analysis (TGA), UV–visible spectra, and mass spectra. The molecular weights of the dimer complexes are measured by GPC (Gel Permeation Chromatography). Characterization of the obtained complexes showed that the NTA ligand coordinates with metal ions in tridentate mode (one N and two COO−) after deprotonation, the creatine molecule coordinates through the carboxylate group, while the dimeric structure of these complexes formed with one of the sulfate groups which coordinates as a bridged bidentate ligand. Investigation of the biological activity of these complexes, as well as their hepatocellular carcinoma (HepG2) cell line inhibitory, has also been achieved.