Abstract
Traditional permeability studies of full-thickness skin have implied molecules permeated through the skin by various polar or nonpolar pathways depending on the hydrophilicity or lipophilicity of the permeant. However, relatively little is known about the structure of stratum corneum, even though it is considered the primary barrier in transdermal permeation of most permeants. Current macroscopic (permeability, differential scanning calorimetry) and molecular (Fourier transform infrared spectroscopy) investigations of the stratum corneum and its components imply hydration and temperature enhanced permeability of lipophilic molecules through the stratum corneum is associated with transitions involving the hydrocarbon chains of the lipid components.
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