Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy.

Elisa Ines Demuner Vallandro,Lucas Nagib Lemos Paulo,Danilo Nagib Salomão Paulo,Luciene Lage Da Motta,Marcela Souza Lima Paulo,Daniel Robert Alexander,Raquel De Azevedo Benevides

doi:10.1590/s0102-865020200090000002

Elisa Ines Demuner Vallandro, Lucas Nagib Lemos Paulo + Show 5 more

Open Access

https://doi.org/10.1590/s0102-865020200090000002

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Abstract

Purpose To evaluate the viability of the upper (UP) and lower pole (LP) of the spleen from a macro and microscopic point of view, after subtotal splenectomy with preservation (SSP) of the UP and the LP.Methods Seventeen male Wistar rats, two months old, were submitted to SSPUP and SSPLP and 5 to simulated operation (SG). After 80 days, the rats were euthanized, and the remaining LP and UP and intact spleens were evaluated macroscopically and microscopically.Results Two rats died during the operation. Macroscopic analysis showed that in 15 LP, one of them was not viable and in 15 UP and in 5 spleens in the SG, all were viable. In the statistical analysis, there was no difference in relation to viability. The LP and UP analyzed showed variation. As for the length, the UP increased significantly; however, in relation to the width, there was a significant increase in the LP in relation to the UP. In addition, the weight of the UP was significantly greater than that of the LP. Microscopic analysis attested viability of the splenic remnants.Conclusion There was no significant difference regarding the viability of UP and LP, in macroscopy and microscopy.

Highlights

Over the years, several studies have demonstrated the importance and usefulness of the spleen on the physiological functioning of the human organism
The present study aims to assess the upper and lower pole of the spleen from a macro and microscopic point of view, after splenectomy of the middle portion of the spleen
At the end of the experiment, the weight of the upper pole was significantly greater than the weight of the lower pole (Table 1)

Summary

Introduction

Several studies have demonstrated the importance and usefulness of the spleen on the physiological functioning of the human organism. Due to the recognition of its important immune function, surgical treatment of total splenectomy is increasingly avoided. For this reason, partial splenectomy has been performed for an increasing number of indications[1]. Partial splenectomy has been performed for an increasing number of indications[1] In addition to these primordial functions, it was demonstrated in an experimental study that the spleen has a role in the lipid metabolism of rats[2]. This result has not been demonstrated in mice[3]

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