Machine Learning Prediction of Liver Allograft Utilization From Deceased Organ Donors Using the National Donor Management Goals Registry.
Several machine learning classifiers were trained to predict transplantation of a liver graft. We utilized 127 variables available in the DMG dataset. We included data from potential deceased organ donors between April 2012 and January 2019. The outcome was defined as liver recovery for transplantation in the operating room. The prediction was made based on data available 12-18 h after the time of authorization for transplantation. The data were randomly separated into training (60%), validation (20%), and test sets (20%). We compared the performance of our models to the Liver Discard Risk Index. Of 13 629 donors in the dataset, 9255 (68%) livers were recovered and transplanted, 1519 recovered but used for research or discarded, 2855 were not recovered. The optimized gradient boosting machine classifier achieved an area under the curve of the receiver operator characteristic of 0.84 on the test set, outperforming all other classifiers. This model predicts successful liver recovery for transplantation in the operating room, using data available early during donor management. It performs favorably when compared to existing models. It may provide real-time decision support during organ donor management and transplant logistics.
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48
- 10.1111/ajt.16411
- Dec 16, 2020
- American Journal of Transplantation
Navigating the COVID-19 pandemic: Initial impacts and responses of the Organ Procurement and Transplantation Network in the United States.
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- Oct 13, 2020
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Maximizing donors' gifts: A comparison of actual and expected solid organ yield among VCA donors.
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- 10.1002/dat.20247
- Nov 1, 2008
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The D&T Report
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29
- 10.1111/j.1600-6135.2004.00394.x
- Apr 1, 2004
- American Journal of Transplantation
Organ donation and transplantation trends in the USA, 2003
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1
- 10.1111/ajt.13741
- Feb 23, 2016
- American Journal of Transplantation
Transplantation on the Rise in Puerto Rico: As its infrastructure grows, Puerto Rico has developed a successful, self-sustaining program.
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23
- 10.1111/ajt.16284
- Sep 27, 2020
- American Journal of Transplantation
Impact of the COVID-19 pandemic on commercial airlines in the United States and implications for the kidney transplant community.
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643
- 10.1034/j.1600-6143.3.s4.11.x
- Apr 1, 2003
- American Journal of Transplantation
Expanded criteria donors for kidney transplantation
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11
- 10.1053/j.ackd.2005.10.004
- Jan 1, 2006
- Advances in Chronic Kidney Disease
Considerations in Retransplantation of the Failed Renal Allograft Recipient
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5
- 10.1111/ajt.16981
- Mar 1, 2022
- American Journal of Transplantation
OPTN/SRTR 2020 Annual Data Report: COVID
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152
- 10.1111/ajt.16010
- Jun 14, 2020
- American Journal of Transplantation
A change of heart: Preliminary results of the US 2018 adult heart allocation revision.
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68
- 10.1002/hep.22135
- Dec 26, 2007
- Hepatology
Model for end-stage liver disease (MELD) for liver allocation: A 5-year score card
- Supplementary Content
348
- 10.1034/j.1600-6143.2002.20804.x
- Sep 1, 2002
- American Journal of Transplantation
Report of the Crystal City Meeting to Maximize the Use of Organs Recovered from the Cadaver Donor
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3
- 10.1097/pcc.0000000000000912
- Oct 1, 2016
- Pediatric Critical Care Medicine
To describe the current practice of pediatric organ donor management in the United States for donors declared dead based upon neurologic criteria. The study directs particular attention to how pediatric donors are defined, the use of donor management guidelines, the use of donor management goals, and the involvement of pediatric critical care or transplantation expertise. Cross-sectional observational study using a web-based survey and follow-up telephone interview with respondents from U.S. organ procurement organizations. The study also incorporated organ procurement organization-specific data on organ yield for the 4-year period (2010-2013) preceding the study. The 58 U.S. organ procurement organizations. Respondents chosen by each organ procurement organization. None. All 58 U.S. organ procurement organizations participated in the study. Fifty-two respondents (90%) indicated that their organ procurement organization distinguished pediatric from adult donors resulting in 28 unique pediatric definitions. Thirty-nine organ procurement organizations utilized some form of written pediatric management guidelines, and 27 (47%) maintained pediatric donor management goals; compliance was infrequently monitored for both guidelines (28%) and goals (33%). A pediatric intensivist was always or usually involved in pediatric donor management at 47 organ procurement organizations (81%); transplant/organ recovery surgeons were always or usually involved at 12 organ procurement organizations (21%). There was an increase in the number of organs transplanted per donor among donors 11-17 years old for organ procurement organizations that used donor management goals for the duration of the period studied (p < 0.01). There was also an increase in the ratio of observed/expected organs transplanted among donors of 0-10 years old for organ procurement organizations that always or usually consulted a transplant/organ recovery surgeon (p = 0.02) although this did not reach our threshold for statistical significance.. There is little consensus among organ procurement organizations regarding the definition of "pediatric" during organ donor management. Most organ procurement organizations employ written pediatric guidelines and use pediatric intensive care physicians for assistance in managing these donors. There is a positive association between the use of donor management goals and organ yield among pediatric donors in the 11- to 17-year age group.
- Supplementary Content
5
- 10.1111/j.1600-6143.2007.02139.x
- Feb 1, 2008
- American Journal of Transplantation
The AJT Report: News and issues that affect organ and tissue transplantation
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14
- 10.1002/lt.23579
- Feb 1, 2013
- Liver Transplantation
Deceased Organ Donor Research: The Last Research Frontier?
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