Abstract
Port wine stain (PWS) is the benign congenital capillary malformation of skin, occurring in 0.3% to 0.5% of the population. In this paper, we build two automated support vector machine (SVM) based classifiers by extracting quantitative features from normal and PWS tissue images recorded by optical coherence tomography (OCT). We use both full feature set and simplified feature set for training. Accuracy of 92.7%, sensitivity of 92.3% and specificity of 93.8% were obtained for classifier with full feature set. Accuracy of 92.7%, sensitivity of 94.9% and specificity of 87.5% were obtained for classifier with simplified feature set. Our results suggest that extracting quantitative features from optical coherence tomographic images could be a potentially powerful method for accurately and automatically identifying PWS margins during laser therapy.
Highlights
Port wine stain (PWS) is the congenital capillary malformation of skin, occurring in 0.3% to 0.5% of the population [1]
We build two automated support vector machine (SVM) based classifiers by extracting quantitative features from normal and PWS tissue images recorded by optical coherence tomography (OCT)
Our results suggest that extracting quantitative features from optical coherence tomographic images could be a potentially powerful method for accurately and automatically identifying PWS margins during laser therapy
Summary
Port wine stain (PWS) is the congenital capillary malformation of skin, occurring in 0.3% to 0.5% of the population [1]. Most lesions initially appear as flat, pink to purple patches. They may progress into hypertrophic, nodular, dark red to dark purple patches with age [2]. About 70% to 80% of PWS occurs in the head and neck regions, which may significantly impact a person’s mental health [3]–[5]. Radiation therapy, freezing, surgical excision, and tattooing used to be performed for PWS treatment [6]. Laser therapy systems become popular because of their abilities to destroy cutaneous vessels while preserving the normal vessels. Among all laser systems, Pulsed dye laser (PDL) remains the clinical gold standard. PDL works by selective photo-thermolysis and about 50% to 70% color reducing of
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