Mace-shaped NH2-Uio-66-modified HNTs as sustained release nanocarrier of loading pyraclostrobin against the grey mould

Abstract

Owing to the high effective release and uptake merits, the ordered porous nanostructure as the drug-loaded delivery nano-systems is fascinating to the sustained release formulations enabled the multi-functional applications. For this reason, we successfully fabricate a novel hierarchal porous nanostructure incorporated with NH2-Uio-66 metal–organic frameworks (MOFs) and halloysite nanotubes (HNTs) that both own the innate lower biotoxicity and good antifungal ability. The composition and structure of the NH2-Uio-66 MOFs@HNTs nanocarrier are determined by a series of characterizations, of which the exclusive morphology manifests the nanosized octahedral structure NH2-Uio-66 MOFs grown on the external surface of HNTs nanotubes, thus looking like mace. As the pyraclostrobin(Pyr)-loaded nano-system, the release performance of Pyr onto NH2-Uio-66 MOFs@HNTs is intensively investigated, and that the release behavior is discussed by the fitting data of the release models. The mace-shaped NH2-Uio-66 MOFs@HNTs nanocarrier has the drug-loaded rate of 11.90% for Pyr by physical adsorption and can release cumulatively by ca.20% at 25 °C for a releasing time of 200 h. Eventually, the Pyr@NH2-Uio-66 MOFs@HNTs as the drug delivery system in the inhibition of strawberry gray mold is manifested to have not only the outstanding sustained release ability to control the grey mould, but also the preferable environment security, which profoundly exhibited the potential application foreground.