Abstract
Metastasis-associated in colon cancer-1 (MACC1) is key in promoting tumor proliferation and invasion, and is mediated by the hepatocyte growth factor (HGF) and mesenchymal-epithelial transition factor. Previous reports have revealed that MACC1 is a novel oncogene that is expressed in various types of gastrointestinal cancer. The present study comprised of 174 patients who underwent curative surgery for colorectal cancer (CRC). The correlation between gene expression and clinical parameters of the patients was assessed. It was identified that patients exhibiting high MACC1 expression levels were statistically more susceptible to distant metastases and a poor prognosis, and those exhibiting low MACC1 expression showed improved disease-free and overall survival than those with high expression. Therefore, the present data indicates that MACC1 expression levels may present as a prognostic factor in CRC patients.
Highlights
In developed countries where the aging population is increasing, cancer is one of the most prominent diseases with regard to public welfare and health measures
hepatocyte growth factor (HGF) activates the HGF/MET signaling pathway, which is involved in metastasis of colorectal cancer (CRC)
Metastasis‐associated in colon cancer‐1 (MACC1) is located on chromosome 7 and was identified through genome‐wide expression analyses conducted on primary and metastatic colon cancer [12]
Summary
In developed countries where the aging population is increasing, cancer is one of the most prominent diseases with regard to public welfare and health measures.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
