Abstract

Spatial distribution of immune cells within the tumor immune microenvironment (TIME) influences response to immunotherapy in many malignancies, but its role in neoadjuvant immunotherapy in non-small cell lung cancer (NSCLC) is not clearly established. To address this knowledge gap, we performed digital pathology analysis of tumor tissue obtained from patients with stage IIIA(N2) NSCLC undergoing neoadjuvant chemotherapy with three cycles of cisplatin/docetaxel followed by treatment with the PD-L1 antibody durvalumab in the single-arm phase II trial SAKK 16/14.

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