Abstract
Acquired resistance of to the initial osimertinib (OSI) therapy remains a majormain issue in thefor treatment of in patients with epidermal growth factor receptor gene (EGFR) mutation-positivemutation positive non-small cell lung cancer (NSCLC) patients. Secondary EGFR mutations or co-existing uncommon EGFR uncommon mutations have been reported as a part of the resistanceresistant mechanisms for of osimertinibOSI. Afatinib (AFA) has a broad range of antitumor activitiesy for athe variety of EGFR mutations.
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