Abstract
RET fusion has been identified as an oncogenic driver in approximately 1-2% of patients with NSCLC. Pralsetinib is a highly potent and selective inhibitor of RET and oncogenic RET alterations. ARROW is a phase I/II, open-label, and first-in-human study to evaluate the safety and antineoplastic activity of pralsetinib in a variety of advanced RET altered solid tumors including NSCLC. Previously we reported the efficacy and safety results of pralsetinib in a cohort of Chinese patients with RET fusion+ NSCLC after platinum-based chemotherapy at WCLC 2020.
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