MA01.04 Molecular Subtypes of Surgically Resected Small Cell Lung Cancer: Expression Pattern and Prognostic Relevance

Abstract

Although our knowledge of small cell lung cancer (SCLC) molecular subtypes has grown significantly over the recent years, translating this information into clinics has been less effective. This may in part be due to the unique nature of SCLC where most patients present at an inoperable stage, and diagnostic biopsies do not provide enough material for profiling studies that can also address tumor heterogeneity. Therefore, the tissue distribution and prognostic relevance of subtype-specific proteins (ASCL1, NEUROD1, POU2F3, YAP1) are largely unexplored in SCLC.