M2013 Cyclic Vomiting Syndrome: Quantitative Pedigree Analysis for Maternal Inheritance Patterns in Adults and Children

Abstract

(18 male, age 28±10), with postprandial fullness, bloating, belching, nausea, epigastric pain, early satiety and vomiting being reported by 85, 70, 70, 56, 67, 48 and 19 % of the patients, respectively; systematic analysis revealed that such pattern of symptoms was quite stable along the times. Although severity was gradually reducing for the majority of the symptoms, only the proportion of patients reporting moderate or severe belching were significantly reduced at 12 months (70 vs. 12 %, p<0.05). At baseline, delayed gastric emptying and impaired satiety testing were present in 60% and 85% of the patients with a similar percentage at 6 months (58 and 90%, respectively). Conclusions: We showed that at least 20% of prospectively evaluated patients with acute gastroenteritis develop and maintain dyspeptic symptoms after the resolution of the acute phase. In these patients symptoms severity was gradually reducing, but still persistent up to 1 year. Persistent delayed gastric emptying of solid meal and impaired gastric accommodation are putative mechanisms involved in symptoms generation.