M1913 A Randomized, Comparative Trial of the Speed of Onset of Symptom Relief of Gastroesophageal Reflux Disease By the Proton Pump Inhibitors: Rabeprazole vs Lansoprazole vs Omeprazole

Abstract

vantaged SES. Univariate analyses did not show associations of lifestyle factors (BMI, smoking, alcohol, marital status) and change in SSS. However, employment status was associated with improvement of SSS (p=.029). In Multiple Linear Regression the set of possible predictors did not explain a significant proportion of differences in symptom severity (p=.099) only SES & employment status were significant. Employed status was associated with less improvement in SSS (2.6 pts < unemployed; p=.008) as was average SES compared to advantaged (3.6 pts < advantaged SES; p=.021). CONCLUSIONS: a) The improvement in reflux symptoms after diagnostic work-up and initiation of therapy in a routine clinical setting can be partly explained by sociodemographic factors b) Paradoxically, advantaged SES and unemployment are each associated with greater improvement of reflux symptoms.