Abstract
to disrupt the abdominal wounds when comparing the results of treated group to those of the control group on POD7 or 21. In regards to abdominal wound collagen content, no differences were noted between the control and treated groups at either time point. Importantly, there were no abdominal wall dehiscence or clinical gastrotomy leaks in CpG treated group. The histologic healing assessment scores were similar between groups. Conclusions: Perioperative administration of CpG doesn't appear to have a negative impact on abdominal wall or gastric wound healing in mice. Although it is not possible to extrapolate these results directly to the human setting, these findings lend support to the concept of a human Phase I perioperative CpG study.
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