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Abstract
negative cancer cells. Lumican mRNA and the protein were detected in all cancer cell lines. The phosphorylation of AKT, known as an important factor in cellular behaviors such as growth, survival, and drug resistance, was up-regulated in lumican knocked down cancer cells. Conclusion: Lumican in cancer cells might inhibit AKT signal pathway and play important roles in effectiveness of anti-cancer drugs in pancreatic cancer patients. It may be a novel candidate for anti-cancer drug via AKT signal pathway.
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