M1199 Atorvastatin Induces Apoptosis In Vitro and Slows Growth of Tumor Xenografts but Does Not Reduce Polyp Initiation

Abstract

endoscopy. CRLs were categorized into adenomatous and serrated lesions. Results A total of 2,310 patients (mean age 58.4 yrs, range 18-93 yrs and 46.1% males) were included. Seventy-nine % of patients were referred due to symptoms, while 20.7% for screening or surveillance indications. In the total population, 37% (n=855) had diverticular disease, of which 77% (n=658) left-sided, 2% (n=16) right-sided and 21% (n=181) generalized. Endoscopic signs of diverticulitis were found in 9.0% (n=77) of the patients with diverticular disease. Of all patients, 27% (n=619) had at least one adenoma and 13% (n=307) at least one serrated lesion. In patients with diverticular disease vs. those without, adenomas were found in 26.8% vs. 17.5% (p<0.001), serrated lesions in 9.5% vs. 6.2% (p=0.004) and both lesions combined in 7.0% vs. 5.2% (p=0.08) of patients, respectively. Multiple logistic regression analysis with interactions, showed that the relationship between diverticular disease and CRLs was affected by age (p<0.001). Presence of diverticular disease was associated with increased risk for CRLs in patients aged <70 yrs (OR 2.2, 95% CI 1.7-3.0, p<0.001), while this was not found in patients aged ≥70 yrs. Noteworthy, the association between diverticular disease and risk for CRLs gradually increased with younger age, as follows: OR 3.0 (95% CI 2.1-4.3, p<0.001) for age <60 yrs, OR 4.5 (95% CI 2.8-7.0, p<0.001) for age <50 yrs and OR 6.6 (95% CI 3.8-11.6, p<0.001) for age <40 yrs. Conclusion We found an age-dependent association between diverticular disease and colorectal lesions. In younger patients diverticular disease is an independent risk factor for simultaneous presence of colorectal lesions, while this is not the case in patients aged 70 yrs or more.