M030 FERRIC CARBOXYMALTOSE DESENSITIZATION IN REFRACTORY IDIOPATHIC IRON-DEFICIENCY ANEMIA, IRON-INFUSION ANAPHYLAXIS, SEVERE ATOPY AND HYPERTRYPTASEMIA

Abstract

Iron-refractory iron-deficient anemia (IRIDA) results from an inadequate iron level with resistance to oral iron (OI) and sometimes partial resistance to intravenous (IV); At least 50 cases have been described. Iron-deficiency anemia (IDA) first-line therapy is OI, but if ineffective, IV dextran, iron sucrose, or ferric carboxymaltose (FCM) is required. FCM is approved for rapid and high-dose replenishment of depleted iron stores and HRs are rare, an estimated <0.1%. Our patient failed OI, had severe anaphylaxis to IV dextran and is at high-risk for hypersensitivity reactions (HR) with chronic urticaria (CU)/dermatographia, dust mite allergic rhinitis, permethrin anaphylaxis and hypertryptasemia; thus FCM-desensitization was performed.