Abstract
Abstract The steady‐state level of a messenger ribonucleic acid (mRNA) is determined by both its rate of synthesis and degradation. The degradation of mRNA is an important tool employed by cells to control gene expression, and to adjust the level of protein synthesis in response to physiological needs. The degradation of mRNA in all organisms is mastered by a rather restricted number of endo‐ and exoribonucleases. Some of these enzymes are phylogenetically conserved across the three domains of life – bacteria, archaea and eukarya. This review provides a brief overview on the major factors and mechanisms involved in bacterial and eukaryal mRNA degradation. Key concepts: Enzymes and factors involved in mRNA decay in prokaryotes and eukaryotes. Mechanisms of mRNA decay in pro‐ and eukaryotes. Defective mRNAs and decay. Noncoding RNAs and mRNA decay.
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