Abstract
In earlier studies we demonstrated that prothymocytes in the 14–22-week-old fetal liver contained receptors for mouse erythrocytes (1,2), and that M receptor is a differentiation marker of fetal and infant thymocytes (3). This report deals with the study of thymocyte subsets and T cell differentiation in human fetal and infant thymus, in which M receptor was used as a marker of T cells. Further, to provide a more composite picture of thymocyte differentiation and compesate the limitations of experimental methods in detecting the cells coexpressing more than two markers, a mathematical probability method defining various membrane phenotypes was used. On the basis of experimentally obtained data and results of regression analysis, a hypothetical pathway of T cell differentiation within the thymus was proposed.KeywordsHuman ThymusFetal ThymusComposite PictureUndergo Heart SurgeryThymocyte DifferentiationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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