M-polynomial and neighborhood M-polynomial of some concise drug structures: Azacitidine, Decitabine and Guadecitabine

Abstract

A topological index is a mathematical value associated with a graph. In chemometrics, biomedicine and bioinformatics, it is widely used to predict various physicochemical properties and biological activities of molecules. Neighborhood M-polynomial (NM-polynomial) is one of such polynomials which is used to obtain many degree-based topological indices. Azacitidine, Decitabine (5-aza-20-deoxycytidine) and Guadecitabine (SGI-110) are hypomethylating agents which are used for the treatments of patients with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukemia and acute myeloid leukemia which are not suitable for in-depth treatments such as induction chemotherapy. In this work, we compute some degree-based and neighborhood degree sum-based indices of the three aforementioned drugs in unified manner by using M-polynomial and NM-polynomial. The findings may aid in the development of novel cancer treatment medicines.