M. Pneumoniae Is a Potential Trigger for Eosinophilic Esophagitis

Abstract

Mycoplasma pneumoniae (MP) is suggested as a trigger of asthma. MP undergoes cyclic epidemics, has increasing macrolide resistance, increases IL-5 and VEGF and contains gene CARDS promoting TH2 inflammation. It has never before to our knowledge been implicated in eosinophilic esophagitis (EOE). We recently treated a 10 year old male for two months of acute onset morning vomiting and cough. He had multiple similarly ill contacts at school. He had failed reflux therapy. EGD showed over 50 eosinophils/HFP in all 3 levels, Ph-impedance probe was normal, MRI of CNS revealed severe pansinusitis.