M.P.3.15 Pupillographic findings in chronic progressive external ophthalmoplegia

Abstract

Systematic data on pupillary function in chronic progressive external ophthalmoplegia (CPEO) does not exist to date. We aimed to characterize the pattern of pupillary function in a homogeneous series of genetically proven CPEO patients. Infrared video pupillography was performed in 15 CPEO patients (mitochondrial DNA deletions in 12, A3243G point mutations in 2, G5835A point mutation in one patient) and 22 age- and sex-matched controls. We determined diameter (PD), early and late redilation velocities (DV) as sympathetic parameters, relative reflex amplitude (RA) and constriction velocity (CV) as parasympathetic parameters, and the pupillary unrest index (PUI) as a measure of vigilance.