M-beat-A novel marker for selective left bundle branch capture.

Abstract

Premature-ventricular-complexes (template/fixation beat) guided left bundle branch pacing (LBBP) was recently described as a novel method of successful lead deployment by rapid rotations. We aimed at analyzing the incidence of a unique morphology template beat, which we labelled as 'M-beat' in patients undergoing PVC-guided LBBP, its ability to predict selective LBB-capture and clinical significance. Overall 210 out of 217 attempted-patients (96.7%) underwent successful LBBP. Template beat was noted in 90.4% patients (n = 190) and M-beat in 32.8%(n = 69). Non-selective to selective capture transition demonstrated in 55.2%(n = 116). The QRS duration of the M-beat was 129.3 ± 13.1ms. Patients were divided into two groups: Group-I with M-beat (n = 69;32.8%) and Group-II without M-beat (n = 141; 67.2%). The mean fluoroscopy-time was significantly less in group-I as compared to group-II (13.1 ± 11.1 vs 16.8 ± 12.04 minutes; p-0.03). Patients in group-II required more attempts as compared to group-I for successful lead deployment (2.8 ± 1.09 vs 2.2 ± 1.04; p - 0.01). Six patients showed loss of R-wave in lead-V1 and 2 showed rise in LBB capture threshold by >1V during follow-up in group-II. M-beat had a specificity of 96.77% and sensitivity of 58.62% (positive-predictive-value-98.55%) to predict selective-LBB capture. Myocardial excitability would not modify the occurrence of M-beat as opposed to capture transition response since it could be demonstrated without pacing protocols. When confirmation of LBB-capture itself would be difficult in patients with baseline LBBB-morphology, M-beat with 42.8% incidence predicted selective capture with 96.7% specificity and 66.04% sensitivity(positive-predictive-value-97.22%). M-beat is a marker of transient-selective LBB-capture, independent of the local myocardial excitability with high specificity and positive predictive value irrespective of the baseline QRS morphology.