M-008 LOWER OXIDIZED LDL AUTOANTIBODIES PREDICT RESTENOSIS IN ACUTE MYOCARDIAL INFARCTION PATIENT AFTER PRIMARY BALLOON ANGIOPLASTY

Abstract

Background Oxidized low-density lipoproteins (ox-LDLs) and their autoantibodies (OLAB) have been detected in human plasma and in atherosclerosis lesion. OLAB have a role in the clearance of oxLDLs from circulation and might be protective against the risk of atherosclerosis. However, the prognostic value of circulating OLAB in patients with acute myocardial infarction (AMI) is unknown. Methods and Results Fifty-eight AMI patients undergoing primary coronary balloon angioplasty were recruited. Plasma levels of oxLDLs and OLAB were measured using competitive ELISA method. Measurements were taken before primary angioplasty, on the 3rd day, on the 7th day and at 1 month after acute event. After 6 month follow-up, angiographic coronary artery restenosis occurred in 18 patients (31%). Plasma OLAB levels were significantly lower in restenosis group. The serial OLAB levels were presented as follows: before PCI (190.9 ± 118.5 vs. 330.8 ± 254.8 U/L, P = 0.006), on the 3rd day (155.2 ± 90.00 vs. 273.6 ± 184.1 U/L, P = 0.004), on the 7th day (189.1 ± 120.2 vs. 337.1 ± 276.0 U/L, P = 0.001) and at 30 days (310.2 ± 305.0 vs. 337.1 ± 326.0 U/L, P = 0.769). However, the serial oxLDLs levels were without significant difference between restenosis and non-restenosis group. The oxLDLs levels before PCI (66.80 ± 19.72 vs. 67.24 ± 22.48 mg/dL, P = 0.939), on the 3rd day (59.25 ± 16.17 vs. 66.33 ± 19.91 mg/dL, P = 0.407), on the 7th day (50.82 ± 12.55 vs. 53.62 ± 16.37, P = 0.514) and at 0 days (54.70 ± 22.11 vs. 60.22 ± 29.70, P = 0.476) were presented. Conclusion Lower levels of circulating OLAB in acute and subacute stage of AMI patients, can predict restenosis of infarct related artery after primary angioplasty. Our data support the notion that OLAB play a role in the maintenance of vascular health.