Abstract
The objective of research study was development of cutting-edge nanoarchitectonic-based nanocage glue for effective wound management. Lysozyme-loaded nanocage glue (NRS) were synthesized, optimized, characterized, and evaluated for drug entrapment efficiency, morphological properties, stability, in-vitro and ex-vivo drug release kinetics, transdermal penetration, and animal wound healing efficacy (in-vivo). The lysozyme-loaded nanocages exhibited desirable characteristics, including ultra-small size (240.1 ± 26.73 nm), higher zeta potential (+17.2 ± 0.24 mV), good entrapment efficiency (90.22 ± 1.67%), spherical hollow shape, and spectral shifts resulting in good entrapment. The lysozyme-loaded nanocages displayed a controlled drug release profile and demonstrated a higher wound healing efficacy, with 87% wound closure rate observed by the 9th day. Results showed that adhesives property resulted in high drug contact time giving fast healing in comparison to the control and other treatments with significant impact on wound healing. In conclusion, the development of the nanocage glue observed to be an effective wound adhesive highlighting its significance for clinical wound healing management. The results suggest that the nanoarchitectonic-based nanocage glue potential candidature for wound healing applications and improved treatments with better outcomes for patients.
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