Abstract
The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed immunohistochemistry to detect cathepsin D in 115 tissue specimens 35 cases showed a positive reaction. In the univariate analysis cathepsin D expression showed significant prognostic value for overall survival (P-value = 0.007). In the multivariate analysis with established prognostic parameters (stage, grade) we found an independent prognostic value for cathepsin D (P-value = 0.002, relative risk = 3.8, 95% confidence interval 1.4 - 10.0). Immunohistochemical detection of cathepsin D could aid in predicting prognosis and planning therapy for patients with endometrial adenocarcinoma.
Highlights
Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer'Institute of Pathologgy, Gynecopathological Unit; 2Departments of Gynecology & Obstetrics and 3Medical Computer Sciences, University of Vienna, Vienna, Austria
S_maary The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma
In endometrial adenocarcinoma cathepsin D levels are higher than in normal endometrium during the follicular phase, but there is no correlation to steroid hormone receptor status (Maudelonde et al, 1990; Nazeer et al, 1994)
Summary
'Institute of Pathologgy, Gynecopathological Unit; 2Departments of Gynecology & Obstetrics and 3Medical Computer Sciences, University of Vienna, Vienna, Austria. S. maary The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. In the univariate analysis cathepsin D expression showed significant prognostic value for overall survival (Pvalue=0.007). Cathepsin D levels are higher in normal human endometrium during the luteal phase than in the follicular phase and increase slightly during pregnancy (Maudelonde et al, 1990). In endometrial adenocarcinoma cathepsin D levels are higher than in normal endometrium during the follicular phase, but there is no correlation to steroid hormone receptor status (Maudelonde et al, 1990; Nazeer et al, 1994). Cathepsin D is a well-known independent prognostic factor in breast cancer, associated with metastasis and overall survival (Spyratos et al, 1989; Tandon et al, 1990; Thorpe et al, 1989). We investigated the prognostic value of cathepsin D in 115 cases of endometrial cancer by immunohistochemistry.
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