Abstract
Lysosomes are highly specialized cellular organelles with crucial functions in metabolic digestion and recycling. They carry a variety of hydrolases that function at low pH and generate specific metabolic products. Work in my laboratory is interested in understanding how these metabolic activities of lysosomes are linked to their signaling communication with other cellular organelles, such as mitochondria, endoplasmic reticulum (ER) and the nucleus. We discovered a lysosome‐to‐nucleus retrograde lipid signaling pathway in promoting healthy aging and metabolic fitness, and revealed its critical roles in the metabolic and signaling interaction between lysosomes and mitochondria. Most recently, we discovered a lysosome‐specific nucleotide hydrolase and its key functions in the control of ER stress responses through interacting with mTOR signaling. These studies highlight the signaling role of lysosomes in the active coordination of cellular homeostasis and in the improvement of the healthy survival of an organism.Support or Funding InformationThis work was supported by HHMI and National Institutes of Health.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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