Abstract
Lysosomes are common vesicular organelles within eukaryotic cells. There are various acidic hydrolases within lysosomes, making these organelles the major site for large biomolecule degradation. Many types of proteins are expressed on the lysosomal membrane, including ion channels, transporters, structural proteins, and enzymatic proteins. Among these lysosomal proteins, ion channels have been found to play important roles in regulating lysosomal ion transportation, lysosomal membrane potential, luminal pH, cellular nutrient metabolism, and homeostasis and have therefore been extensively investigated. Several lysosome-specific ion channels have been identified in recent years. In this review, we briefly summarize research studies on various types of lysosomal membrane ion channels and explore their characteristics, regulation, and roles in physiological activities of lysosomes.
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