Abstract
Swainsonine reversibly inhibits macrophage lysosomal acid α-mannosidase in vitro. When supplied to cultured cells for periods of up to 24 h, swainsonine penetrates the cells and produces a dose- and time-dependent inhibition of cellular α-mannosidase. Exposure of macrophages to swainsonine for 24 h, followed by continued incubation in the absence of this agent, produces elevated cellular activity of α-mannosidase, relative to unexposed controls; prolonged incubation of macrophage cultures with swainsonine for 1–2 weeks results also in significant increases in cell protein, lactate dehydrogenase activity and in that of another lysosomal enzyme, β-hexosaminidase.
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