Abstract
Background and Aims: Lysophosphatidylcholine (LysoPC) has been shown to induce the expression of inflammatory proteins, including cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6), associated with cardiac fibrosis. Whether COX-2 induced IL-6 secretion in human cardiac fibroblasts (HCFs) was still unknown. Therefore, we aimed to investigate the mechanisms by which LysoPC primed NOX/ROS-JNK1/2-dependent NF-κB and FoxO1 activation, leading to COX-2-induced IL-6 expression in HCFs.
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