Abstract
Membrane stabilizing effects of cholesterol on the permeability of K+ and change in membrane potential induced with lysolecithin were investigated. Cholesterol inhibited K+ release from rabbit red blood cells treated with lysolecithin. 3.3 X 10(-6)M of cholesterol was the optimum concentration required to inhibit K+ release from rabbit red blood cells treated with lysolecithin (1.25 microgram/ml) at the level of 100 percent. Change in membrane potential was evident with lysolecithin by the method of fluorescent dye and, cholesterol inhibited the change which was dose dependent. These inhibitory effects of cholesterol on the K+ release and changes in membrane potential served as the membrane stabilizing action on red blood cell membrane. It is assumed that cholesterol acts as an inhibitor to increase membrane fluidity and permeability of malignant transformed cells such as tumor and lymphoid cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
