Lysine-specific histone demethylase 1A mediates oxidative stress, inflammation, and atherogenesis in apolipoprotein E-deficient mice; prospective implications for human atherosclerosis

Abstract

Background and Aims : Epigenetic mechanisms play a major role in the pathophysiology of cardiovascular diseases. The implication of histone methylation-based regulatory mechanisms in atherosclerosis remains poorly understood. We aimed at investigating the potential role of lysine-specific histone demethylase 1A (KDM1A) in the regulation of key down-stream molecular effectors and pathways linked to atherosclerotic plaque formation.