Abstract

The metabolism of l-lysine, l-pipecolate, and saccharopine was studied in rabbits. The results indicated the existence of the same metabolic pathways as have been delineated in other species. The rabbit differed from the other species studied previously since saccharopine, l-pipecolate, and d-lysine were all readily converted to CO 2. The only endogenous source of pipecolate detected in rabbits was the catabolism of the d-lysine which had been injected. No pipecolate was produced from l-lysine under these experimental conditions. These data indicated that the major pathway for l-lysine catabolism in rabbits involved saccharopine as an intermediate. The existence of an alternate route involving pipecolate cannot be ruled out, but was indicated to be of very minor importance in l-lysine catabolism.

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