Lyophilized hydroalcoholic extract of Passiflora edulis and Zea mays L, as potential arterial hypotension and hypocholesterolemia in hypertensive Mus musculus induced hypertension

Abstract

The leaves of Zea mays L and Passiflora edulis have multipurpose for conventional medicine for their bioactive compounds, however, their use in animal models lacks demonstration and biomedical valida-tion, hence the objective was to evaluate the effect of lyophilized extract of P. edulis Sims and Z. mays L as a potential arterial hypotensive and induce hypocholesterolemia in hypertensive Swiss albino mice. Forty-eight 8-week-old Swiss albino mice were used by dividing into 4 groups: G1- passion fruit (50 mg [n= 4], 100 mg [n= 4], and 200 mg [n= 4]), G2-purple corn (50 mg [n= 4], 100 mg [n= 4], and 200 mg [n= 4]), and G3-controls: negative control (distilled water [n= 12]), G4-positive control (N-nitro-L-arginine methyl ether (L-NAME) [n= 12]). Mice were fasted to assess systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), glucose and cholesterol at base-line and post induction with L-NAME by indirect method. At 4 weeks of study the animals of G1-passion fruit and G2-purple corn showed significant antihypertensive and hypocholesterolemia effect (p<0.05) resulting the concentration 200 mg as optimal reducer and stabilizer of SBP, DBP, MAP, glucose and cholesterol. In conclusion, the lyophilized extract of P. edulis (passion fruit) and Z. mays L (purple corn) leaves at 200 mg concentration showed excellent antihypertensive and hypocholesterol-emia effects in hypertensive Swiss albino mice.