Abstract
We have prepared solid dispersions (melt, coprecipitate) of nordazepam III (NDZ) with carriers polyoxyethylene glycol (PEG 6000), succinic acid, and with another drug, nicotinic acid, corresponding to the eutectic composition. From a study of the dissolution kinetics, we found that the highest value is obtained for the PEG 6000 melt. We have shown that there is a good correlation between PEG solid dispersion dissolution kinetics and mixing enthalpies.
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