Abstract
Lymphotoxin (LT) is a TNF family cytokine. Blocking of LTalpha(Α)1beta(Β)2–LTBreceptor (LTΒR) interactions prevents experimental colitis and other experimental autoimmune disease in mice, suggesting a potential treatment principle of human inflammatory bowel disease (IBD). Infection of mice with Citrobacter rodentium (C. r.) serves as an animal model for human infectious colitis induced by enteropathogen E. coli (EPEC).
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