Abstract
This study aimed to confirm the presence of Blocking Factors (BFs) in Mixed Lymphocyte Culture (MLC) from female normal reproducer and sub-fertile rabbit inoculated with two injection of the allogenic lymphotherapy (LIT) to analyze its effect on rate fertility and pregnancy success. The BFs measuring was done intervening MLC with MTT-Formazan non-radioactive technique. It was demonstrated BFs presence in MLC in female rabbit groups.. In sub-fertile female reproducers treated with allogenic lymphotherapy a significant increase in the level of FBs after every LIT was observed, as well as a rate fertility increase.. Furthermore, it was established that BFs act on cell proliferation inhibiting the MLC of other species, clearly indicating that the inhibit effect of the BFs is inter-specific and no intraspecific as had sustain until now.
Highlights
In 1994 Beer and Billingham established the bases of the immunology of reproduction
This study aimed to confirm the presence of Blocking Factors (BFs) in Mixed Lymphocyte Culture (MLC) from female normal reproducer and sub-fertile rabbit inoculated with two injection of the allogenic lymphotherapy (LIT) to analyze its effect on rate fertility and pregnancy success
BFs results from control females rabbit were obtained, mean 28,69 %, value considered as reference for normal reproducer females without allogenic Lymphotherapy treatment
Summary
In 1994 Beer and Billingham established the bases of the immunology of reproduction These initial studies demonstrated that the uterus is not a immunology privileged tissue. They postulated different theories to explain the survival of fetal allograft during the pregnancy and established the immunotherapy as treatment to recurrent spontaneous miscarriage [1]. It is currently accepted that the mothers recognize immunologically to her allogenic embryo and respond strongly to the blastocyst implantation in endometrium. For this reason has been thought that there are factors that regulate or suppress the immunological response against the embryo in development, allowing to success of the placental mammals from mammals perspective [4]
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