Abstract
The purpose of the present study was to evaluate the lymphoproliferative response of submandibular nodes cells to stimulation by phytohemagglutinin (PHA), concanavalin A (Con A), and lipopolysaccharide (LPS) following experimental gingivitis in dogs.In 4 dogs of the experimental group, gingival inflammation was induced by cervical ligatures on the left jaw, and the right jaw was kept clean by toothbrushing. In 2 dogs of the control group, toothbrushing was performed throughout. After the weight and lymphocyte number in the submandibular nodes were calculated, the lymphocyte response was determined by the uptake of 3H‐thymidine.The weight and lymphocyte number of the ipsilateral nodes increased 2.2 and 3.7 times, respectively, as compared with the contralateral nodes. There was a higher background proliferation of unstimulated lymphocytes from ipsilateral nodes. The lymphocyte response to lower PHA concentration from ligated side lymphnodes significantly increased compared to that from contralateral nodes. It is suggested that the plaque accumulation and the intensive gingival inflammation considerably influence lymphocytes in the submandibular nodes.
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