Abstract
Lymphomas affecting major salivary glands are quite uncommon, and the sublingual glands are the rarest affected glands, with few case series available in the literature. Therefore, This study aimed to investigate the clinicopathological features of a series of lymphomas affecting the sublingual glands. Cases diagnosed in four pathology services were assessed, and clinical data were obtained from patients' medical files. In total, seven cases of lymphomas involving the sublingual gland were identified, with four in women and three in men, with a mean age of 64.3 years, all of whom presented a clinical picture of asymptomatic swellings. Two were follicular lymphomas, two diffuse large B-cell lymphomas not otherwise specified (DLBCL NOS), two MALT lymphomas, and one mantle cell lymphoma. In all cases the neoplastic cells infiltrated the glandular parenchyma. Only a single patient (diagnosed with DLBCL, NOS) died, while the other six patients were alive at the last follow-up. Lymphomas affecting major salivary glands are quite uncommon, and the sublingual glands are the rarest affected glands, with few case series available in the literature. Therefore, This study aimed to investigate the clinicopathological features of a series of lymphomas affecting the sublingual glands. Cases diagnosed in four pathology services were assessed, and clinical data were obtained from patients' medical files. In total, seven cases of lymphomas involving the sublingual gland were identified, with four in women and three in men, with a mean age of 64.3 years, all of whom presented a clinical picture of asymptomatic swellings. Two were follicular lymphomas, two diffuse large B-cell lymphomas not otherwise specified (DLBCL NOS), two MALT lymphomas, and one mantle cell lymphoma. In all cases the neoplastic cells infiltrated the glandular parenchyma. Only a single patient (diagnosed with DLBCL, NOS) died, while the other six patients were alive at the last follow-up.
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