Lymphoma or Pseudolymphoma, that is the Question

Yasar Albushra Ahmed

doi:10.23937/2378-3656/1410035

Abstract

Lymphoma or Pseudolymphoma, that is the Question

Highlights

We describe the case of a 15-year-old man with history of resected astrocytoma and seizure disorder
Clonal population of T-cells could not be detected in a pathologic specimen obtained from an excisional biopsy of one of the patient’s cervical lymph nodes, such finding argues against lymphoma
This experience demonstrates that combining clinical history, histological and immunohistochemical findings is crucial for a definite diagnosis of pseudolymphoma syndrome

Summary

Introduction

We describe the case of a 15-year-old man with history of resected astrocytoma and seizure disorder. Clonal population of T-cells could not be detected in a pathologic specimen obtained from an excisional biopsy of one of the patient’s cervical lymph nodes, such finding argues against lymphoma. This experience demonstrates that combining clinical history, histological and immunohistochemical findings is crucial for a definite diagnosis of pseudolymphoma syndrome. The Histopathological assessment of the cervical lymph node was highly suggestive of lymphoma It showed diffuse proliferation of various size atypical lymphocytes (Figure 2). The T-cell receptor gene rearrangement clonality study and the EBV in-situ hybridization were negative (Figure 3) He was monitored for signs of clinical recovery. No recurrence of symptoms occurred in the 3-month follow-up period

Discussion

Conclusion